Ethyl bromoacetate → HCID 13773141, compound

HRID 235906Notes

Reaction equation

HRID 235906 reaction equation
[F:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][C:10]([C:12]2[CH:16]=[CH:15][O:14][CH:13]=2)=[O:11])=[O:7])=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH:9]([C:10]([C:12]2[CH:16]=[CH:15][O:14][CH:13]=2)=[O:11])[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:7])=[CH:17][CH:18]=1

Participants

4

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 137870254-Fluoro-N-[2-(furan-3-yl)-2-oxoethyl]benzamide

Product 1

HCID 13773141HCID 13773141, compoundYield 69.8%

Procedure

8.5 g of N-(4-fluorobenzoyl)-(3-furylcarbonyl)methylamine, 1.6 g of 61% sodium hydride and 6.3 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 8.0 g of ethyl 3-(4-fluorobenzoylamino)-3-(3-furylcarbonyl)propionate are thereby obtained. Yield: 69.6%

Workup

  1. customas described in Preparation 1-(2)

Sources & evidence

ORD record
ord-6321f5bead18403ca40de725a25c1ac0
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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