Dimethylformamide dimethyl acetal → HCID 67260953, compound

HRID 2359060Notes

Reaction equation

HRID 2359060 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:7](=[O:9])[CH3:8])[S:5][CH:6]=1.CO[CH:12](OC)[N:13]([CH3:15])[CH3:14]>>[Br:1][C:2]1[CH:3]=[C:4]([C:7](=[O:9])[CH:8]=[CH:12][N:13]([CH3:15])[CH3:14])[S:5][CH:6]=1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 27352371-(4-Bromo-2-thienyl)ethan-1-one

Product 1

HCID 67260953HCID 67260953, compoundYield 99.2%

Procedure

A mixture of 1-(4-bromo-2-thienyl)ethanone (48.8 mmol) and N,N-dimethylformamide dimethyl acetal (73.1 mmol) was refluxed overnight and then allowed to cool to room temperature. The reaction mixture was concentrated under reduced pressure and dried in vacuo to afford 12.6 g (99% yield) of 1-(4-bromo-2-thienyl)-3-(dimethylamino)prop-2-en-1-one which was used in the next step without further purification.

Workup

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customdried in vacuo

Sources & evidence

ORD record
ord-a89ff86b284346bba4f46838e4ce926c
Source dataset
uspto-grants-2014_04
Patent number
US08685974B2

Reaction notes

Loading…