反应详情

A mixture of 1-(4-methyl-2-thienyl)ethanone (70.8 mmol) and N,N-dimethylformamide dimethyl acetal (105.1 mmol) was refluxed overnight and then allowed to cool to room temperature. The reaction mixture was concentrated under reduced pressure and dried in vacuo to afford 13.8 g (100% yield) of 3-(dimethylamino)-1-(4-methyl-2-thienyl)prop-2-en-1-one which was used in the next step without further purification.

1. temperaturewas refluxed overnight
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customdried in vacuo