Dimethylformamide dimethyl acetal → HCID 2766362, compound

HRID 2359064Notes

Reaction equation

HRID 2359064 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[S:5][C:6]=1[Br:7].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[Br:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH:9]=[CH:13][N:14]([CH3:16])[CH3:15])[S:5][C:6]=1[Br:7]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 27645761-(4,5-Dibromo-2-thienyl)-1-ethanone

Product 1

HCID 2766362HCID 2766362, compoundYield 98.5%

Procedure

A mixture of 1-(4,5-dibromo-2-thienyl)ethanone (9.7 mmol) and N,N-dimethylformamide dimethyl acetal (44.8 mmol) was refluxed for 3 h and then allowed to cool to room temperature. The reaction mixture was concentrated under reduced pressure and dried in vacuo to afford 3.24 g (94% yield) of 1-(4,5-dibromo-2-thienyl)-3-(dimethylamino)prop-2-en-1-one which was used in the next step without further purification.

Workup

  1. temperaturewas refluxed for 3 h
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customdried in vacuo

Sources & evidence

ORD record
ord-535ddf09a25144bcaadff8017ee6b9f4
Source dataset
uspto-grants-2014_04
Patent number
US08685974B2

Reaction notes

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