Hydrazine hydrate (1:1) → HCID 178419313, compound

HRID 2359065Notes

Reaction equation

HRID 2359065 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8](=O)[CH:9]=[CH:10][N:11](C)C)[S:5][C:6]=1[Br:7].O.[NH2:16]N>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][NH:11][N:16]=2)[S:5][C:6]=1[Br:7]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 2766362HCID 2766362, compound

Product 1

HCID 178419313HCID 178419313, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1-(4,5-dibromo-2-thienyl)-3-(dimethylamino)prop-2-en-1-one (9.6 mmol) and hydrazine hydrate (14.3 mmol) in 22 mL ethanol was refluxed for 15 h and then allowed to cool to room temperature. The solvent was evaporated under reduced pressure and dried in vacuum to afford 2.94 g (100% yield) 3-(4,5-dibromo-2-thienyl)-1H-pyrazole which was used in the next step without further purification.

Workup

  1. temperaturewas refluxed for 15 h
  2. customThe solvent was evaporated under reduced pressure
  3. customdried in vacuum

Sources & evidence

ORD record
ord-c0184364af104833bccf84b7ed11a321
Source dataset
uspto-grants-2014_04
Patent number
US08685974B2

Reaction notes

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