Ethyl bromoacetate → HCID 13773142, compound

HRID 235908Notes

Reaction equation

HRID 235908 reaction equation
[C:1]([NH:9][CH2:10][C:11]([C:13]1[CH:17]=[CH:16][O:15][CH:14]=1)=[O:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[C:1]([NH:9][CH:10]([C:11]([C:13]1[CH:17]=[CH:16][O:15][CH:14]=1)=[O:12])[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 13773129N-[2-(Furan-3-yl)-2-oxoethyl]benzamide

Product 1

HCID 13773142HCID 13773142, compoundYield 86%

Procedure

7.8 g of N-benzoyl-(3-furylcarbonyl)methylamine, 1.6 g of 61% sodium hydride and 6.3 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 9.2 g of ethyl 3-benzoylamino-3-(3-furylcarbonyl)propionate are thereby obtained. Yield: 86.0%

Workup

  1. customas described in Preparation 1-(2)

Sources & evidence

ORD record
ord-0aa79325357641a0866f0f0f5d5f07eb
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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