Ethyl bromoacetate → HCID 13773143, compound

HRID 235910Notes

Reaction equation

HRID 235910 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[Cl:19])[C:5]([NH:7][CH2:8][C:9]([C:11]1[CH:15]=[CH:14][O:13][CH:12]=1)=[O:10])=[O:6].[H-].[Na+].Br[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[Cl:19])[C:5]([NH:7][CH:8]([C:9]([C:11]1[CH:15]=[CH:14][O:13][CH:12]=1)=[O:10])[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[O:6]

Participants

4

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 137731303,4-Dichloro-N-[2-(furan-3-yl)-2-oxoethyl]benzamide

Product 1

HCID 13773143HCID 13773143, compoundYield 91.9%

Procedure

7.6 g of N-(3,4-dichlorobenzoyl)-(3-furylcarbonyl)methylamine, 1.2 g of 61% sodium hydride and 4.7 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 9.0 g of ethyl 3-(3,4-dichlorobenzoylamino)-3-(3-furylcarbonyl)propionate are thereby obtained. Yield: 91.9%

Workup

  1. customas described in Preparation 1-(2)

Sources & evidence

ORD record
ord-0a9599ee4bd1484bacc75cb36437b913
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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