Hydroxylamine → HCID 22575065, compound

HRID 23593Notes

Reaction equation

HRID 23593 reaction equation
[NH:1]([CH2:5][C:6]([O-:8])=O)[C:2]([NH2:4])=[O:3].[NH2:9][OH:10]>O1CCOCC1>[OH:10][NH:9][C:6](=[O:8])[CH2:5][NH:1][C:2]([NH2:4])=[O:3]

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 6988657Carbamoyl glycine

Product 1

HCID 22575065HCID 22575065, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The ArgoGel-Wang or ArgoGel-OH resin bound 2-ureidoacetate 6 (0.25 g) was treated with dioxane (1 mL) and aqueous 50% hydroxylamine (2 mL). After 24 h the resin was filtered, washed with acetonitrile and the filtrates combined and purified by preparative reverse-phase (C18) HPLC to yield product N-hydroxy-2-ureidoacetamide (I).

Workup

  1. filtrationAfter 24 h the resin was filtered
  2. washwashed with acetonitrile
  3. custompurified by preparative reverse-phase (C18) HPLC

Sources & evidence

ORD record
ord-8682a78de8b54b0786af40fdd48aff5a
Source dataset
uspto-grants-2005_02
Patent number
US06852752B2

Reaction notes

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