1,4-Dioxane hydrochloride → HCID 66990412, compound

HRID 2359345Notes

Reaction equation

HRID 2359345 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[N:9][CH:8]=[C:7]2[N:14]1[CH2:19][CH2:18][CH2:17][CH:16]([CH2:20][O:21][CH2:22][CH2:23][NH:24]C(=O)OC(C)(C)C)[CH2:15]1)(=[O:3])[NH2:2].[ClH:32].O1CCOCC1>O1CCOCC1>[ClH:32].[NH2:24][CH2:23][CH2:22][O:21][CH2:20][CH:16]1[CH2:17][CH2:18][CH2:19][N:14]([C:7]2[C:6]3[C:11](=[CH:12][CH:13]=[C:4]([C:1]([NH2:2])=[O:3])[CH:5]=3)[CH:10]=[N:9][CH:8]=2)[CH2:15]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 56840223HCID 56840223, compound

Product 1

HCID 66990412HCID 66990412, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Tert-butyl (2-{[1-(6-carbamoylisoquinolin-4-yl)piperidin-3-yl]methoxy}ethyl)carbamate (158 mg, 0.368 mmol) produced in Example 21 was dissolved in dioxane (5 mL), to which a 4M hydrochloric acid/dioxane solution (2 mL) was added, followed by stirring overnight at room temperature. Upon completion of the reaction, the solvent was distilled off under reduced pressure to give the desired title compound (148 mg, yield 100%).

Workup

  1. additionwas added
  2. customUpon completion of the reaction
  3. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-e4f1044de67849e7998e4e88c70e007c
Source dataset
uspto-grants-2014_04
Patent number
US08685981B2

Reaction notes

Loading…