1,4-Dioxane hydrochloride → HCID 66990412, compound

Participants

Reaction Steps

Tert-butyl (2-{[1-(6-carbamoylisoquinolin-4-yl)piperidin-3-yl]methoxy}ethyl)carbamate (158 mg, 0.368 mmol) produced in Example 21 was dissolved in dioxane (5 mL), to which a 4M hydrochloric acid/dioxane solution (2 mL) was added, followed by stirring overnight at room temperature. Upon completion of the reaction, the solvent was distilled off under reduced pressure to give the desired title compound (148 mg, yield 100%).

Provenance & Evidence