HCID 58495703, compound → HCID 58495748, compound

Participants

Reaction Steps

Benzyl 4-[2-(tetrahydro-2H-pyran-4-yloxy)ethoxy]piperidine-1-carboxylate (505 mg, 1.39 mmol) produced in Reference Example 1 (1e) was dissolved in methanol (15 mL), to which palladium hydroxide (50 mg) was added, followed by stirring at room temperature for 18 hours under a hydrogen atmosphere. The resulting reaction liquid was filtered through Celite, and the solvent was distilled off under reduced pressure to give the desired title compound (318 mg, yield 100%).

Provenance & Evidence