HCID 58495703, compound → HCID 58495748, compound

HRID 2359347Notes

Reaction equation

HRID 2359347 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([O:7][CH2:8][CH2:9][O:10][CH:11]2[CH2:16][CH2:15][N:14](C(OCC3C=CC=CC=3)=O)[CH2:13][CH2:12]2)[CH2:3][CH2:2]1>CO.[OH-].[Pd+2].[OH-]>[O:1]1[CH2:2][CH2:3][CH:4]([O:7][CH2:8][CH2:9][O:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH2:5][CH2:6]1

Participants

4

Reactant 1

HCID 58495703HCID 58495703, compound

Product 1

HCID 58495748HCID 58495748, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

Benzyl 4-[2-(tetrahydro-2H-pyran-4-yloxy)ethoxy]piperidine-1-carboxylate (505 mg, 1.39 mmol) produced in Reference Example 1 (1e) was dissolved in methanol (15 mL), to which palladium hydroxide (50 mg) was added, followed by stirring at room temperature for 18 hours under a hydrogen atmosphere. The resulting reaction liquid was filtered through Celite, and the solvent was distilled off under reduced pressure to give the desired title compound (318 mg, yield 100%).

Workup

  1. additionwas added
  2. customThe resulting reaction liquid
  3. filtrationwas filtered through Celite
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-a4a8c54b01aa4c94bf796f81f67c79a4
Source dataset
uspto-grants-2014_04
Patent number
US08685981B2

Reaction notes

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