(1,4-Dioxan-2-yl)methanol → HCID 58495831, compound

HRID 2359353Notes

Reaction equation

HRID 2359353 reaction equation
CC1C=CC(S([O:11][CH2:12][CH2:13][O:14][CH:15]2[CH2:20][CH2:19][N:18](C(OCC3C=CC=CC=3)=O)[CH2:17][CH2:16]2)(=O)=O)=CC=1.[O:31]1[CH2:36][CH2:35][O:34][CH2:33][CH:32]1[CH2:37]O>>[O:31]1[CH2:36][CH2:35][O:34][CH2:33][CH:32]1[CH2:37][O:11][CH2:12][CH2:13][O:14][CH:15]1[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]1

Participants

3

Reactant 2

HCID 12655091(1,4-Dioxan-2-yl)methanolHCID 58495736HCID 58495736, compound

Product 1

HCID 58495831HCID 58495831, compoundYield 118.8%

Procedure

Using benzyl 4-(2-{[(4-methylphenyl)sulfony]oxy}ethoxy)piperidine-1-carboxylate (7.8 g, 18.0 mmol) produced in Reference Example 1 (1c) and 1,4-dioxan-2-ylmethanol (1.78 g, 15.1 mmol), the desired title compound (4.4 g, yield 61%) was obtained by the same method as in Reference Examples 1 (1d) and 1 (1e).

Sources & evidence

ORD record
ord-130296b72d4341a79296cd6c5d29f0ac
Source dataset
uspto-grants-2014_04
Patent number
US08685981B2

Reaction notes

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