Trifluoroacetic acid → Trifluoroacetic acid

HRID 2359362Notes

Reaction equation

HRID 2359362 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:12][CH:13]2[CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].[C:24]([OH:30])([C:26]([F:29])([F:28])[F:27])=[O:25]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:12][CH:13]2[CH2:14][NH:15][CH2:16]2)[CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10].[C:24]([OH:30])([C:26]([F:29])([F:28])[F:27])=[O:25]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 70145969HCID 70145969, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 66185179HCID 66185179, compound

Procedure

To tert-butyl 3-(3-methoxy-4-nitrophenylamino)azetidine-1-carboxylate (9 g) was added TFA (18 mL) at room temperature. The reaction mixture was stirred for 15 min at room temperature and then was concentrated under reduced pressure at 40° C. to give the title compound as TFA salt (7.24 g).

Workup

  1. concentrationwas concentrated under reduced pressure at 40° C.

Sources & evidence

ORD record
ord-742a1555f7b54dbf867267730e1b9923
Source dataset
uspto-grants-2014_04
Patent number
US08685988B2

Reaction notes

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