HCID 178521466, compound → HCID 178521465, compound

HRID 235939Notes

Reaction equation

HRID 235939 reaction equation
[CH2-]C(C)=O.[S:5]1[CH:9]=[CH:8][CH:7]=[C:6]1[C:10]1[N:11]=[C:12]([C:15]2[CH:26]=[CH:25][C:18]([O:19][CH2:20][CH:21]([OH:24])[CH2:22][OH:23])=[CH:17][CH:16]=2)[NH:13][CH:14]=1>Cl.CC(C)=O>[S:5]1[CH:9]=[CH:8][CH:7]=[C:6]1[C:10]1[N:11]=[C:12]([C:15]2[CH:16]=[CH:17][C:18]([O:19][CH2:20][CH:21]([OH:24])[CH2:22][OH:23])=[CH:25][CH:26]=2)[NH:13][CH:14]=1

Participants

4

Reactant 1

HCID 178521466HCID 178521466, compound

Product 1

HCID 178521465HCID 178521465, compoundYield 86.6%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 3-[p-[4-(2-thienyl)-2-imidazolyl]phenoxy]-1,2-propanediol acetonide (14.15 g, 0.04 m) in 3N HCl (80 ml) and acetone (80 ml) is refluxed for 0.5 hours. Acetone is removed under reduced pressure and the aqueous mixture is rendered alkaline with K2CO3. The solid is collected and dried in a vacuum oven at 60° C. to yield (III) (10.38 g, 82%, m.p. 197°-200° C.).

Workup

  1. temperatureis refluxed for 0.5 hours
  2. customAcetone is removed under reduced pressure
  3. customThe solid is collected
  4. customdried in a vacuum oven at 60° C.

Sources & evidence

ORD record
ord-276afd9c0347413db529e0443b908bbc
Source dataset
uspto-grants-1987_02
Patent number
US04642311

Reaction notes

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