反应详情

温度

140 °C

A solution of N-(2-chloroquinolin-8-yl)thiazole-4-carboxamide (29 mg, 0.100 mmol), 3-fluorophenylboronic acid (28 mg, 2 eq.), CsCO3 (65 mg, 2 eq.), Pd(dppf)Cl2.DCM (4 mg, 0.05 eq.) in DME (2 mL) was microwave heated (140° C.×15 min.). The reaction was filtered and concentrated. The residue was diluted with ethyl acetate, washed with saturated aqueous NaHCO3, dried (Na2SO4) and concentrated. The product was purified by column chromatography (0 to 100% EtOAc in Pentane) to obtain 8.6 mg of N-(2-(3-fluorophenyl)quinolin-8-yl)thiazole-4-carboxamide. MS (ESI) calcd for C19H13FN3OS (m/z): 350.08. found: 350.1 [M+1].

1. filtrationThe reaction was filtered
2. concentrationconcentrated
3. additionThe residue was diluted with ethyl acetate
4. washwashed with saturated aqueous NaHCO3
5. dry with materialdried (Na2SO4)
6. concentrationconcentrated
7. customThe product was purified by column chromatography (0 to 100% EtOAc in Pentane)