HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2359395Generated: November 3, 2026
Dichloromethane → N-(2-(3-fluorophenyl)quinolin-8-yl)thiazole-4-carboxamide
https://huagongshe.com/reaction/2359395
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| Reactant | HCID 58154776 | HCID 58154776 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | N-(2-(3-fluorophenyl)quinolin-8-yl)thiazole-4-carboxamide | HCID 58154579 | 24.6% |
Reaction Steps
A solution of N-(2-chloroquinolin-8-yl)thiazole-4-carboxamide (29 mg, 0.100 mmol), 3-fluorophenylboronic acid (28 mg, 2 eq.), CsCO3 (65 mg, 2 eq.), Pd(dppf)Cl2.DCM (4 mg, 0.05 eq.) in DME (2 mL) was microwave heated (140° C.×15 min.). The reaction was filtered and concentrated. The residue was diluted with ethyl acetate, washed with saturated aqueous NaHCO3, dried (Na2SO4) and concentrated. The product was purified by column chromatography (0 to 100% EtOAc in Pentane) to obtain 8.6 mg of N-(2-(3-fluorophenyl)quinolin-8-yl)thiazole-4-carboxamide. MS (ESI) calcd for C19H13FN3OS (m/z): 350.08. found: 350.1 [M+1].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08685970B2 |
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| Source dataset | uspto-grants-2014_04 |
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| ORD ID | ord-b5c8fe3f17674216b68bd51e0425a86e |
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| Source note | uspto-grants-2014_04 |
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