HRID2359401
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
产物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
A mixture of 2-chloro-N-(pyridin-3-ylmethyl)quinolin-8-amine (160 mg, 0.59 mmol), 3-pyridylboronic acid (111 mg, 0.9 mmol), PdCl2(dppf).CH2Cl2 complex (53 mg, 0.06 mmol), K2CO3 (248 mg, 1.8 mmol) and dioxane/H2O (5:1, 6 ml) was stirred at 80° C. for 3 h under N2. The reaction was filtered, concentrated and purified by prepTLC (4:1 pentane/ethyl acetate) to give 2-(pyridin-3-yl)-N-(pyridin-3-ylmethyl)quinolin-8-amine as a yellow solid (139 mg, yield 75%). MS (ESI) calcd for C20H16N4 (m/z): 312.14. found: 313 [M+1].
WORKUP
后处理
- filtrationThe reaction was filtered
- concentrationconcentrated
- custompurified by prepTLC (4:1 pentane/ethyl acetate)