反应详情

温度

50 °C

A solution of 3-(3,4-dimethoxyphenyl)-2-propylamine (20.0 g, 0.10 m) in isopropanol (20 ml) is heated to 50° C. while a solution of glycidol (5.0 g, 0.067 m) in isopropanol (5 ml) is added over 15 minutes. The mixture is stirred at 50° C. for 0.5 hours and then at 70° C. for 16 hours. The solvent is concentrated under reduced pressure and the residue is chromatographed on silica gel, eluting with 10% MeOH-CHCl3 saturated with NH3 to yield (I) weighing 14.37 g (80%).

1. additionis added over 15 minutes
2. waitat 70° C. for 16 hours
3. concentrationThe solvent is concentrated under reduced pressure
4. customthe residue is chromatographed on silica gel
5. washeluting with 10% MeOH-CHCl3 saturated with NH3