HCID 178488918, compound → HCID 178488919, compound

HRID 235944Notes

Reaction equation

HRID 235944 reaction equation
[Br:1][C:2]1[N:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)[NH:5][C:6]=1C(O)=O>Cl>[Br:1][C:2]1[N:3]=[C:4]([C:10]2[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=2)[NH:5][CH:6]=1

Participants

3

Reactant 1

HCID 178488918HCID 178488918, compound

Product 1

HCID 178488919HCID 178488919, compoundYield 78.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of 9 (2.6 g, 0.0088 mol) in 8N HCl (100 ml) was heated at reflux for 20 hours. The solution was then cooled and filtered to yield 1.75 g (70%) of 10.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 20 hours
  3. temperatureThe solution was then cooled
  4. filtrationfiltered

Sources & evidence

ORD record
ord-bb7a766d28274b70813d19e716579525
Source dataset
uspto-grants-1987_02
Patent number
US04642311

Reaction notes

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