Thionyl Chloride → HCID 58154605, compound

HRID 2359440Notes

Reaction equation

HRID 2359440 reaction equation
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:5]=[C:6]([C:10]2[CH:11]=[CH:12][C:13]3[N:14]=[CH:15][N:16]=[C:17](O)[C:18]=3[N:19]=2)[CH:7]=[CH:8][CH:9]=1.O=S(Cl)[Cl:25]>>[Cl:25][C:17]1[C:18]2[N:19]=[C:10]([C:6]3[CH:7]=[CH:8][CH:9]=[C:4]([O:3][C:2]([F:22])([F:21])[F:1])[CH:5]=3)[CH:11]=[CH:12][C:13]=2[N:14]=[CH:15][N:16]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 178517959HCID 178517959, compound

Product 1

HCID 58154605HCID 58154605, compound

Procedure

A solution of 6-(3-(trifluoromethoxy)phenyl)pyrido[3,2-d]pyrimidin-4-ol (1.2 g, 3.9 mmol) in SOCl2 (10 mL) was refluxed for 2 hours. The reaction was concentrated under reduce pressure, and the residue was chased with toluene (10 mL) to obtain 4-chloro-6-(3-(trifluoromethoxy)phenyl)pyrido[3,2-d]pyrimidine as a brown solid. Used as is without further purification.

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-09f5cea663dd41db8e0fc9a4cb21fce1
Source dataset
uspto-grants-2014_04
Patent number
US08685970B2

Reaction notes

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