HRID2359564

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2764053

6-Chloronicotinaldehyde

C6H4ClNO

HCID17060766

1-Methylpiperazin-2-one--hydrogen chloride (1/1)

C5H11ClN2O

PRODUCTS

产物

HCID58315473

未命名化合物

收率 84.1%

PROCEDURE

实验过程

Following General Method B, 6-chloro-pyridine-3-carbaldehyde (500 mg, 3.532 mmol) and 1-methylpiperazine-2-one hydrochloride (559 mg, 3.709 mmol) gave 4-(6-chloro-pyridin-3-ylmethyl)-1-methyl-piperazin-2-one (712 mg, 84%) [following SiO2 chromatography, eluting with 0-10% MeOH/dichloromethane]. MS (ESI) m/z 240.1 (M+H)+