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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2359564Generated: October 30, 2026

6-Chloropyridine-3-carbaldehyde → HCID 58315473, compound

https://huagongshe.com/reaction/2359564

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Chloropyridine-3-carbaldehydeHCID 2764053—
Reactant1-Methylpiperazin-2-one--hydrogen chloride (1/1)HCID 17060766—
ProductHCID 58315473HCID 5831547384.1%

Reaction Steps

Following General Method B, 6-chloro-pyridine-3-carbaldehyde (500 mg, 3.532 mmol) and 1-methylpiperazine-2-one hydrochloride (559 mg, 3.709 mmol) gave 4-(6-chloro-pyridin-3-ylmethyl)-1-methyl-piperazin-2-one (712 mg, 84%) [following SiO2 chromatography, eluting with 0-10% MeOH/dichloromethane]. MS (ESI) m/z 240.1 (M+H)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08685980B2
Source datasetuspto-grants-2014_04
ORD IDord-a370763993274e82816c84d7f17aec16
Source noteuspto-grants-2014_04