Trifluoroacetic acid → HCID 58247412, compound

HRID 2359656Notes

Reaction equation

HRID 2359656 reaction equation
C(OC([NH:8][C:9]1[CH:30]=[CH:29][C:12]([O:13][C:14]2[C:19]([C:20]([OH:22])=[O:21])=[CH:18][N:17]=[C:16]([C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)[N:15]=2)=[CH:11][CH:10]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][C:9]1[CH:30]=[CH:29][C:12]([O:13][C:14]2[C:19]([C:20]([OH:22])=[O:21])=[CH:18][N:17]=[C:16]([C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)[N:15]=2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58247437HCID 58247437, compound

Product 1

HCID 58247412HCID 58247412, compoundYield 202.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of Compound 17b (1.5 g; 3.6 mmol) in CH2Cl2 (30 mL) was adde TFA (10 mL). The solution was stirred at room temperature for 1.5 h, and the solvent was evaporated in vacuo. The residue was triturated with Et2O, collected the solid and dried to afford the title Compound 17c (2.25 g; 96% yield based on tri-TFA salt). MS: m/z 309.2 (M+H)+.

Workup

  1. customthe solvent was evaporated in vacuo
  2. customThe residue was triturated with Et2O
  3. customcollected the solid
  4. customdried

Sources & evidence

ORD record
ord-049a235aab5643bc974a512edf3b0a03
Source dataset
uspto-grants-2014_04
Patent number
US08685990B2

Reaction notes

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