Ammonia → HCID 178488972, compound

HRID 235969Notes

Reaction equation

HRID 235969 reaction equation
[C:1]([C:5]1[N:6]=[C:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)[NH:8][CH:9]=1)(OC)=[O:2].[NH3:18]>CO>[C:1]([C:5]1[N:6]=[C:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)[NH:8][CH:9]=1)(=[O:2])[NH2:18]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178498875HCID 178498875, compound

Product 1

HCID 178488972HCID 178488972, compoundYield 64.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 63 (21 g, 0.09 mol), CH3OH (700 ml) and NH3 (250 g) was heated in a sealed tube at 120° C. for 24 hours. After washing out the contents, the suspension was concentrated to dryness and the residue crystallized from CH3OH to yield 12.6 g (64%) of 64.

Workup

  1. washAfter washing out the contents
  2. concentrationthe suspension was concentrated to dryness
  3. customthe residue crystallized from CH3OH

Sources & evidence

ORD record
ord-f3438cbf267044958194867de46ece28
Source dataset
uspto-grants-1987_02
Patent number
US04642311

Reaction notes

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