HCID 178430846, compound → HCID 178430845, compound

HRID 235973Notes

Reaction equation

HRID 235973 reaction equation
[CH2-]C(C)=O.[CH3:5][C:6]1[N:7]=[C:8]([C:11]2[CH:22]=[CH:21][C:14]([O:15][CH2:16][CH:17]([OH:20])[CH2:18][OH:19])=[CH:13][CH:12]=2)[NH:9][CH:10]=1>Cl.CC(C)=O>[CH3:5][C:6]1[N:7]=[C:8]([C:11]2[CH:22]=[CH:21][C:14]([O:15][CH2:16][CH:17]([OH:20])[CH2:18][OH:19])=[CH:13][CH:12]=2)[NH:9][CH:10]=1

Participants

4

Reactant 1

HCID 178430846HCID 178430846, compound

Product 1

HCID 178430845HCID 178430845, compoundYield 71.8%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 79 (8.8 g, 0.031 m) in 3N HCl (70 ml) and acetone (70 ml) was refluxed for 45 minutes. Acetone was removed under reduced pressure and the aqueous mixture rendered alkaline with K2CO3. The solid was collected and dried in a vacuum oven at 60° C. to yield 80 (5.14 g, 67%, m.p. 196°-199° C.).

Workup

  1. temperaturewas refluxed for 45 minutes
  2. customAcetone was removed under reduced pressure
  3. customThe solid was collected
  4. customdried in a vacuum oven at 60° C.

Sources & evidence

ORD record
ord-887c4335c15f49f394dadb823c607107
Source dataset
uspto-grants-1987_02
Patent number
US04642311

Reaction notes

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