1,4-Dioxane → HCID 68550929, compound

HRID 2359845Notes

Reaction equation

HRID 2359845 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH:4]=O.[F:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[C:13]=1[CH2:20][CH2:21][C:22]#[N:23].O1CCOCC1>C(O)(C)(C)C>[Cl:10][C:7]1[CH:6]=[C:3]2[C:2](=[CH:9][CH:8]=1)[N:1]=[C:22]([NH2:23])[C:21]([CH2:20][C:13]1[C:14]([O:18][CH3:19])=[CH:15][CH:16]=[CH:17][C:12]=1[F:11])=[CH:4]2

Participants

5

Reactant 3

HCID 312751,4-DioxaneHCID 27738982-Amino-5-chlorobenzaldehydeHCID 68550217HCID 68550217, compound

Product 1

HCID 68550929HCID 68550929, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

The title compound was synthesized according to EXAMPLE 11 from 2-amino-5-chlorobenzaldehyde and 3-(2-fluoro-6-methoxyphenyl)propionitrile. Instead of dioxane, tert-butanol was used from [sic; as] the solvent. Reaction time: 5 minutes at 120° C.

Workup

  1. customReaction time
  2. custom5 minutes
  3. customat 120° C.

Sources & evidence

ORD record
ord-deba9e7f978e4c6da9dd83542bb43299
Source dataset
uspto-grants-2014_04
Patent number
US08686002B2

Reaction notes

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