HCID 18349590, compound → HCID 16045947, compound

HRID 2359867Notes

Reaction equation

HRID 2359867 reaction equation
F[C:2](F)(F)[C:3]([OH:5])=O.[NH2:8][C:9]1[C:10]([CH:15]=O)=[N:11][CH:12]=[CH:13][CH:14]=1.CO[C:19]1[CH:24]=[CH:23]C=C[C:20]=1[CH2:25][CH2:26][C:27]#[N:28].[CH3:29]C([O-])(C)C.[K+]>>[CH3:29][O:5][C:3]1[CH:2]=[CH:23][CH:24]=[CH:19][C:20]=1[CH2:25][C:26]1[C:27]([NH2:28])=[N:8][C:9]2[C:10]([CH:15]=1)=[N:11][CH:12]=[CH:13][CH:14]=2

Participants

4

Reactant 3

HCID 18349590HCID 18349590, compoundHCID 23665647Potassium tert-butoxideHCID 86098791HCID 86098791, compound

Product 1

HCID 16045947HCID 16045947, compound

Procedure

The title compound was synthesized according to EXAMPLE 11 from 3-amino-2-pyridine carboxaldehyde trifluoroacetate (in turn synthesized from (2-formylpyridin-3-yl)carbamate tert-butyl ester by treatment with trifluoroacetic acid) and 3-(2-methoxyphenyl)propionitrile. One equivalent of potassium tert-butylate was additionally used.

Sources & evidence

ORD record
ord-b2236520e32e4b318970e2b86699e7a1
Source dataset
uspto-grants-2014_04
Patent number
US08686002B2

Reaction notes

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