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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2359888Generated: November 3, 2026

Hydrochloric Acid → HCID 68546769, compound

https://huagongshe.com/reaction/2359888

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 131731281HCID 131731281—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 68546769HCID 68546769—

Reaction Steps

Splitting off the Boc group starting from 5.16 g tert-butyl-4-[3-(2-methoxybenzyl)-3,4-dihydroquinazolin-2-yl]piperazine 1-carboxylate with 4N HCl in dioxane and basic workup yielded the desired product: 3.24 g.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08686002B2
Source datasetuspto-grants-2014_04
ORD IDord-48d4e3e69520406ea9738a4b5aeb0e54
Source noteuspto-grants-2014_04