Hydrochloric Acid → HCID 68546769, compound

HRID 2359888Notes

Reaction equation

HRID 2359888 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:23]([CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[O:31][CH3:32])[CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[CH3:32][O:31][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[CH2:24][N:23]1[CH2:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:15]=[C:14]1[N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131731281HCID 131731281, compound

Product 1

HCID 68546769HCID 68546769, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Splitting off the Boc group starting from 5.16 g tert-butyl-4-[3-(2-methoxybenzyl)-3,4-dihydroquinazolin-2-yl]piperazine 1-carboxylate with 4N HCl in dioxane and basic workup yielded the desired product: 3.24 g.

Sources & evidence

ORD record
ord-48d4e3e69520406ea9738a4b5aeb0e54
Source dataset
uspto-grants-2014_04
Patent number
US08686002B2

Reaction notes

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