反应详情

146 mg (585 μmol) of 6-[1-(pyridin-3-yl)-1H-pyrazol-4-yl]pyridine-2-amine and 54.0 μl (701 μmol) of N-methylmorpholine were initially charged in 10 ml of dichloromethane, and methanesulphonyl chloride was added at room temperature. The mixture was stirred overnight and the reaction mixture was filtered through silica gel (eluent: ethyl acetate). After concentration, the crude product was purified by chromatography (dichloromethane/methanol).

1. filtrationthe reaction mixture was filtered through silica gel (eluent: ethyl acetate)
2. concentrationAfter concentration
3. customthe crude product was purified by chromatography (dichloromethane/methanol)