Water → 7-amino-8-(2-methylpropyl)-6-nitroso-2,3-dihydroimidazo[1,2-a]pyrimidin-5-one

HRID 235998Notes

Reaction equation

HRID 235998 reaction equation
[NH2:1][C:2]1[N:3]([CH2:12][CH:13]([CH3:15])[CH3:14])[C:4]2[N:5]([CH2:9][CH2:10][N:11]=2)[C:6](=[O:8])[CH:7]=1.O.[N:17]([O-])=[O:18].[Na+]>CC(O)=O>[NH2:1][C:2]1[N:3]([CH2:12][CH:13]([CH3:15])[CH3:14])[C:4]2[N:5]([CH2:9][CH2:10][N:11]=2)[C:6](=[O:8])[C:7]=1[N:17]=[O:18]

Participants

5

Reactant 3

HCID 962WaterHCID 131005547-AMINO-2,3-DIHYDRO-8-(2-METHYLPROPYL)IMIDAZO[1,2-a]PYRIMIDIN-5(8H)-ONEHCID 23668193Sodium Nitrite

Product 1

HCID 1784484267-amino-8-(2-methylpropyl)-6-nitroso-2,3-dihydroimidazo[1,2-a]pyrimidin-5-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 5.00 g. (0.024 mole) of the product of Procedure 30 in 15 ml. H2O and 4 ml. HOAc (0°) was added (portionwise) 1.72 g. (0.024 mole) NaNO2. The mixture was stirred at 24° for 30 min., cooled to 0° and filtered to yield 4.44 g. (72%) of a purple solid, mp 203°-205°d.

Workup

  1. temperaturecooled to 0°
  2. filtrationfiltered
  3. customto yield 4.44 g

Sources & evidence

ORD record
ord-4a78f15917c64849b1b1e32a349ba1d8
Source dataset
uspto-grants-1987_02
Patent number
US04642345

Reaction notes

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