Isobutylamine → HCID 13391417, compound

HRID 236002Notes

Reaction equation

HRID 236002 reaction equation
Br[C:2]1[N:10]([CH3:11])[C:9]2[C:8](=[O:12])[N:7]3[CH2:13][CH2:14][N:15]=[C:6]3[N:5]([CH2:16][C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[C:4]=2[N:3]=1.[CH3:24][CH:25]([CH3:28])[CH2:26][NH2:27]>C(O)C>[Cl:23][C:20]1[CH:21]=[CH:22][C:17]([CH2:16][N:5]2[C:4]3[N:3]=[C:2]([NH:27][CH2:26][CH:25]([CH3:28])[CH3:24])[N:10]([CH3:11])[C:9]=3[C:8](=[O:12])[N:7]3[CH2:13][CH2:14][N:15]=[C:6]23)=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 6558IsobutylamineHCID 12683883HCID 12683883, compound

Product 1

HCID 13391417HCID 13391417, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of the product of Procedure 46, 1.0 g. (0.0025 mole) and 0.37 g. (0.005 mole) of 2-methylpropylamine in 20 ml. of ethanol is refluxed for 16 hrs. The desired product precipitated as the hydrobromide salt which was collected and mixed with dilute aqueous sodium hydroxide to convert it into the free base form, m.p. 185°-187°.

Workup

  1. customThe desired product precipitated as the hydrobromide salt which
  2. customwas collected
  3. additionmixed with dilute aqueous sodium hydroxide

Sources & evidence

ORD record
ord-0468be095c154520a93013c08303dabd
Source dataset
uspto-grants-1987_02
Patent number
US04642345

Reaction notes

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