Citric Acid → HCID 86658825, compound

HRID 2360070Notes

Reaction equation

HRID 2360070 reaction equation
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[C:30]([OH:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([OH:40])=[O:39])([C:34]([OH:36])=[O:35])[OH:33]>CO>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[C:30]([O-:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([O-:40])=[O:39])([C:34]([O-:36])=[O:35])[OH:33]

Participants

4

Reactant 2

HCID 311Citric AcidHCID 5329102Sunitinib

Product 1

HCID 86658825HCID 86658825, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Sunitinib (2.21 g, 5.55 mmol) suspended in methanol (75 ml), 1.07 g of citric acid was added. Mixture was stirred at room temperature for several hours, and then filtered to obtain crystalline sunitinib citrate, 3.2 g. Melting point: 166-174° C. (Form I).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-778ef29c63e241ab82928d8080f28ebb
Source dataset
uspto-grants-2014_04
Patent number
US08686023B2

Reaction notes

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