Citric Acid → HCID 86658825, compound

HRID 2360077Notes

Reaction equation

HRID 2360077 reaction equation
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[C:30]([OH:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([OH:40])=[O:39])([C:34]([OH:36])=[O:35])[OH:33].CO>O>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[C:30]([O-:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([O-:40])=[O:39])([C:34]([O-:36])=[O:35])[OH:33]

Participants

5

Reactant 3

HCID 311Citric AcidHCID 887MethanolHCID 5329102Sunitinib

Product 1

HCID 86658825HCID 86658825, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sunitinib (2.25 g, 5.65 mmol) and citric acid (1.09 g, 5.65 mmol) were dissolved while heating in the mixture of methanol (100 ml) and water (10 ml). The solution was left to cool to room temperature to give sunitinib citrate. Melting point: 168-173° C. (Form I).

Workup

  1. waitThe solution was left

Sources & evidence

ORD record
ord-271aa0259be646e59081d0d20cab9e21
Source dataset
uspto-grants-2014_04
Patent number
US08686023B2

Reaction notes

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