Citric Acid → HCID 86658825, compound

HRID 2360079Notes

Reaction equation

HRID 2360079 reaction equation
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[C:30]([OH:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([OH:40])=[O:39])([C:34]([OH:36])=[O:35])[OH:33]>C(O)C>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:12]([CH3:29])=[C:13](/[CH:17]=[C:18]2/[C:19]3[CH:20]=[C:21]([F:28])[CH:22]=[CH:23][C:24]=3[NH:25][C:26]/2=[O:27])[NH:14][C:15]=1[CH3:16])=[O:10])[CH2:4][CH3:5].[C:30]([O-:42])(=[O:41])[CH2:31][C:32]([CH2:37][C:38]([O-:40])=[O:39])([C:34]([O-:36])=[O:35])[OH:33]

Participants

4

Reactant 2

HCID 311Citric AcidHCID 5329102Sunitinib

Product 1

HCID 86658825HCID 86658825, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sunitinib (1.45 g, 3.64 mmol) was dissolved in boiling ethanol (140 ml), then citric acid (0.23 g, 1.21 mmol) was added to the solution, which was left to cool to room temperature to give sunitinib citrate with melting points 166-170° C. (Form I) and 219-224° C. (Form III).

Workup

  1. waitwas left

Sources & evidence

ORD record
ord-0eea0d8f364448e5bd62aac05a351155
Source dataset
uspto-grants-2014_04
Patent number
US08686023B2

Reaction notes

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