2-Naphthyl isocyanate → HCID 86659868, compound

HRID 2360139Notes

Reaction equation

HRID 2360139 reaction equation
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([OH:17])=[CH:14][CH:15]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][C:19]=1[N:28]=[C:29]=[O:30]>>[CH:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][C:19]=1[NH:28][C:29](=[O:30])[O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:9][CH2:10]2

Participants

3

Reactant 2

HCID 167182-Naphthyl isocyanateHCID 866598571-Benzylindolin-5-ol

Product 1

HCID 86659868HCID 86659868, compound

Procedure

The title compound was synthesized from 1-benzylindolin-5-ol (15.0 mg, 66.6 μmol) using the same procedure employed for Example 2 (2), but with 2-naphthylisocyanate instead of 4-isopropylphenylisocyanate. The product was obtained as a white solid (14.4 mg, 55%) having the following characteristics.

Sources & evidence

ORD record
ord-e4301918d00245f8be460e082bcb7fdc
Source dataset
uspto-grants-2014_04
Patent number
US08686024B2

Reaction notes

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