2-Fluoro-5-methoxyphenylboronic acid → HCID 66996748, compound

HRID 2360444Notes

Reaction equation

HRID 2360444 reaction equation
Br[C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([Cl:10])[CH:3]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=1B(O)O>>[Cl:10][C:4]1[CH:3]=[C:2]([C:13]2[CH:14]=[C:15]([O:18][CH3:19])[CH:16]=[CH:17][C:12]=2[F:11])[CH:8]=[C:7]([F:9])[C:5]=1[NH2:6]

Participants

3

Reactant 2

HCID 41572112-Fluoro-5-methoxyphenylboronic acidHCID 204346204-Bromo-2-chloro-6-fluoroaniline

Product 1

HCID 66996748HCID 66996748, compoundYield 59%

Procedure

The title compound (70 mg) was prepared from 4-bromo-2-chloro-6-fluoroaniline (100 mg, 0.44 mmol) and 2-fluoro-5-methoxyphenylboronic acid (98 mg, 0.58 mmol) as a white solid. 1H-NMR (δ ppm, DMSO-d6, 400 MHz): 7.30-7.24 (m, 2H), 7.17 (t, J 9.1, 1H), 7.02-6.97 (m, 1H), 6.90-6.84 (m, 1H), 5.61 (s, 2H), 3.77 (s, 3H).

Sources & evidence

ORD record
ord-bec2e9434bb8472580a9815e146f83cf
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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