反应详情

50 g N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulphonamid hydrochloride (J. Med. Chem. 2007, 50 (17), 4016-26) are suspended in 200 ml of water and 600 ml of ethyl acetate and sufficient 4 N sodium hydroxide solution is added with vigorous stirring to give a pH of 11. Then the phases are separated, the aqueous phase is extracted with ethyl acetate and the combined organic phases are dried on magnesium sulphate and evaporated down in vacuo. The solid thus obtained is further reacted directly.

1. customto give a pH of 11
2. customThen the phases are separated
3. extractionthe aqueous phase is extracted with ethyl acetate
4. customthe combined organic phases are dried on magnesium sulphate
5. customevaporated down in vacuo
6. customThe solid thus obtained
7. customis further reacted directly