HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 66986037, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 76803534 | HCID 76803534 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 66986037 | HCID 66986037 | — |
Reaction Steps
1.59 g tert-butyl [5-tert-butyl-2-methoxy-3-({1-methyl-7-[4-(1-methyl-pyrrolidine-2-carbonyl)-piperazin-1-ylmethyl]-1H-indole-2-carbonyl}-amino)-phenyl]-carbamate are dissolved in 15 ml dichloromethane, combined with 10 ml of a 5 M solution of hydrogen chloride in isopropanol and stirred for 3 hours at ambient temperature. Then the solvents are eliminated in vacuo. The product thus obtained is further reacted directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08686022B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-10f45afe418a485398b96817618349de |
| Source note | uspto-grants-2014_04 |