Hydrochloric Acid → HCID 66986037, compound

HRID 2360497Notes

Reaction equation

HRID 2360497 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([NH:21][C:22]([C:24]2[N:25]([CH3:48])[C:26]3[C:31]([CH:32]=2)=[CH:30][CH:29]=[CH:28][C:27]=3[CH2:33][N:34]2[CH2:39][CH2:38][N:37]([C:40]([CH:42]3[CH2:46][CH2:45][CH2:44][N:43]3[CH3:47])=[O:41])[CH2:36][CH2:35]2)=[O:23])[C:8]([O:19][CH3:20])=[C:9]([NH:11]C(=O)OC(C)(C)C)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:49]>ClCCl.C(O)(C)C>[ClH:49].[ClH:49].[ClH:49].[NH2:11][C:9]1[C:8]([O:19][CH3:20])=[C:7]([NH:21][C:22]([C:24]2[N:25]([CH3:48])[C:26]3[C:31]([CH:32]=2)=[CH:30][CH:29]=[CH:28][C:27]=3[CH2:33][N:34]2[CH2:35][CH2:36][N:37]([C:40]([C@@H:42]3[CH2:46][CH2:45][CH2:44][N:43]3[CH3:47])=[O:41])[CH2:38][CH2:39]2)=[O:23])[CH:6]=[C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])[CH:10]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 76803534HCID 76803534, compound

Product 1

HCID 66986037HCID 66986037, compound

Reagents, catalysts & solvents 2

HCID 3776IsopropanolSolventHCID 6344DichloromethaneSolvent

Procedure

1.59 g tert-butyl [5-tert-butyl-2-methoxy-3-({1-methyl-7-[4-(1-methyl-pyrrolidine-2-carbonyl)-piperazin-1-ylmethyl]-1H-indole-2-carbonyl}-amino)-phenyl]-carbamate are dissolved in 15 ml dichloromethane, combined with 10 ml of a 5 M solution of hydrogen chloride in isopropanol and stirred for 3 hours at ambient temperature. Then the solvents are eliminated in vacuo. The product thus obtained is further reacted directly.

Workup

  1. customThe product thus obtained
  2. customis further reacted directly

Sources & evidence

ORD record
ord-10f45afe418a485398b96817618349de
Source dataset
uspto-grants-2014_04
Patent number
US08686022B2

Reaction notes

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