Methyl 5-tert-butyl-2-methoxy-3-nitro-benzoate → Methyl 3-amino-5-tert-butyl-2-methoxy-benzoate

Participants

Reaction Steps

2.7 g methyl 5-tert-butyl-2-methoxy-3-nitro-benzoate are dissolved in 120 ml of methanol, combined with 270 mg of 10% palladium on charcoal and hydrogenated for 12 hours at ambient temperature and 4 bar hydrogen pressure. Then the catalyst is filtered off, the solvents are eliminated in vacuo and the residue thus obtained is further reacted directly.

Provenance & Evidence