3-(Morpholin-4-yl)aniline → HCID 46190508, compound

HRID 2360523Notes

Reaction equation

HRID 2360523 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[CH2:11][N:12]2[CH2:17][CH2:16][N:15]([C:18]([CH:20]3[CH2:24][CH2:23][CH2:22][N:21]3[CH3:25])=[O:19])[CH2:14][CH2:13]2)[CH:4]=[C:3]1[C:26](O)=[O:27].[N:29]1([C:35]2[CH:36]=[C:37]([NH2:41])[CH:38]=[CH:39][CH:40]=2)[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1.N1(OC(N(C)C)=[N+](C)C)C2N=CC=CC=2N=N1.F[P-](F)(F)(F)(F)F>>[N:29]1([C:35]2[CH:36]=[C:37]([NH:41][C:26]([C:3]3[N:2]([CH3:1])[C:10]4[C:5]([CH:4]=3)=[CH:6][CH:7]=[CH:8][C:9]=4[CH2:11][N:12]3[CH2:13][CH2:14][N:15]([C:18]([C@@H:20]4[CH2:24][CH2:23][CH2:22][N:21]4[CH3:25])=[O:19])[CH2:16][CH2:17]3)=[O:27])[CH:38]=[CH:39][CH:40]=2)[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1

Participants

4

Reactant 3

HCID 8477683-(Morpholin-4-yl)anilineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 66769300HCID 66769300, compound

Product 1

HCID 46190508HCID 46190508, compound

Procedure

1-methyl-7-[4-(1-methyl-pyrrolidine-2-carbonyl)-piperazin-1-ylmethyl]-1H-indole-2-carboxylic acid and 3-morpholin-4-yl-phenylamine are used as reactants. O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium-hexafluorophosphate (HATU) is used instead of O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium-tetrafluoroborate (TBTU).

Sources & evidence

ORD record
ord-4b84387755c44949a354e22b61c37645
Source dataset
uspto-grants-2014_04
Patent number
US08686022B2

Reaction notes

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