Methyl Methanesulfonate → HCID 178505332, compound

HRID 2360594Notes

Reaction equation

HRID 2360594 reaction equation
[CH3:1][N:2]1[C@@H:7]2[C@@H:8]3[O:10][C@@H:9]3[C@H:3]1[CH2:4][CH:5]([O:11][C:12]([C:14]([OH:25])([C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)[C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)=[O:13])[CH2:6]2.[CH3:26][S:27]([O:30]C)(=[O:29])=[O:28]>C(#N)C>[CH3:1][N+:2]1([CH3:26])[C@@H:3]2[C@@H:9]3[O:10][C@@H:8]3[C@H:7]1[CH2:6][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)[C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)=[O:13])[CH2:4]2.[CH3:26][S:27]([O-:30])(=[O:29])=[O:28]

Participants

4

Reactant 2

HCID 4156Methyl MethanesulfonateHCID 29927228Scopine-2,2-dithienyl glycolate

Product 1

HCID 178505332HCID 178505332, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
55 °C

Procedure

75.5 g scopine di-(2-thienyl)glycolate are dissolved in 750 ml acetonitrile while heating gently. After the addition of 22 ml of methyl methanesulphonate the mixture is stirred at 55° C. After the reaction has ended about 350 ml solvent distilled off under reduced pressure. The product crystallises out and is filtered off. It is purified by recrystallisation from methanol/acetone.

Workup

  1. temperaturewhile heating gently
  2. distillationdistilled off under reduced pressure
  3. customThe product crystallises out
  4. filtrationis filtered off
  5. customIt is purified by recrystallisation from methanol/acetone

Sources & evidence

ORD record
ord-7e863d57f0b04fa2991affecf8a4e66f
Source dataset
uspto-grants-2014_04
Patent number
US08686148B2

Reaction notes

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