Hydrochloric Acid → 2-(4-Hydroxyphenyl)propionic acid

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Reaction Steps

To a solution of potassium hydroxide (0.185 g; 0.0039 mole) in water (18 ml), 2-(1'-bromoethyl)-5,5-dimethyl-2-(4'-hydroxyphenyl)-1,3-dioxane (1 g, 0.0031 mole) is added, and the mixture is kept under a nitrogen atmosphere at room temperature for 30 minutes. After this time, potassium hydroxide (0.5 g; 0.089 mole) is added, and the mixture is refluxed for 1 hour. The reaction mixture is then submitted to successive treatments with HCl, with NaHCO3 and once again with HCl as described in Example 1c. 2-(4'-Hydroxyphenyl)-propionic acid is obtained (0.385 g; 0.0023 mole; yield of 75%). Its characteristics are identical to those given for the product of Example 1.

Provenance & Evidence