Hydrochloric Acid → 2-(4-Hydroxyphenyl)propionic acid

HRID 236061Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 236061
[OH-].[K+].Br[CH:4]([C:6]1([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=2)OCC(C)(C)CO1)C.Cl.[C:22]([O-])([OH:24])=[O:23].[Na+]>O>[OH:20][C:17]1[CH:16]=[CH:15][C:14]([CH:6]([CH3:4])[C:22]([OH:24])=[O:23])=[CH:19][CH:18]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric Acid2×HCID 14797Potassium Hydroxide2×HCID 516892Sodium BicarbonateHCID 202181682-(1'-Bromoethyl)-5,5-dimethyl-2-(4'-hydroxyphenyl)-1,3-dioxane

Produkt 1

HCID 1025262-(4-Hydroxyphenyl)propionic acidAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of potassium hydroxide (0.185 g; 0.0039 mole) in water (18 ml), 2-(1'-bromoethyl)-5,5-dimethyl-2-(4'-hydroxyphenyl)-1,3-dioxane (1 g, 0.0031 mole) is added, and the mixture is kept under a nitrogen atmosphere at room temperature for 30 minutes. After this time, potassium hydroxide (0.5 g; 0.089 mole) is added, and the mixture is refluxed for 1 hour. The reaction mixture is then submitted to successive treatments with HCl, with NaHCO3 and once again with HCl as described in Example 1c. 2-(4'-Hydroxyphenyl)-propionic acid is obtained (0.385 g; 0.0023 mole; yield of 75%). Its characteristics are identical to those given for the product of Example 1.

Aufarbeitung

  1. temperaturethe mixture is refluxed for 1 hour

Quellen und Nachweise

ORD-Eintrag
ord-9ff36f3677b94018b82aaa78c5d3a121
Quelldatensatz
uspto-grants-1987_02
Patentnummer
US04642376

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