反应详情

温度

75 °C

A mixture of 3-amino-5-methylpyrazole (50.0 g), pyruvic acid methyl ester (58.4 g) and 4-hydroxybenzaldehyde (62.9 mL) in acetic acid/methanol (v/v=1/1, 300 mL) was stirred at 75° C. for 15 h, cooled to r.t.; and the precipitate formed was isolated by suction filtration and dried in vacuo at 60° C. 15 g (10%) of the title compound were obtained as pale yellow solid.

1. temperaturecooled to r.t.
2. customand the precipitate formed
3. customwas isolated by suction filtration
4. customdried in vacuo at 60° C