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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2360690Generated: October 31, 2026

Hydrochloric Acid → HCID 178434397, compound

https://huagongshe.com/reaction/2360690

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant6-(4-Hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (4-methyl-piperidin-4-yl)-amideHCID 136359772—
SolventTetrahydrofuranHCID 8028—
ProductHCID 178434397HCID 178434397118.1%

Reaction Steps

A solution of 6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid (4-methyl-piperidin-4-yl)-amide (75 mg) in THF (1 mL) was added to a stirred solution of HCl (4N in dioxane). The mixture was stirred at r.t. overnight, the precipitate formed was filtered off and washed with ethyl acetate and acetone and dried in air to give 72 mg (99%) of the title compound as hydrochloride

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08686150B2
Source datasetuspto-grants-2014_04
ORD IDord-013566ac2b2a45b3b71b057b2fd9f1a5
Source noteuspto-grants-2014_04