HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178434397, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-(4-Hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (4-methyl-piperidin-4-yl)-amide | HCID 136359772 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178434397 | HCID 178434397 | 118.1% |
Reaction Steps
A solution of 6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid (4-methyl-piperidin-4-yl)-amide (75 mg) in THF (1 mL) was added to a stirred solution of HCl (4N in dioxane). The mixture was stirred at r.t. overnight, the precipitate formed was filtered off and washed with ethyl acetate and acetone and dried in air to give 72 mg (99%) of the title compound as hydrochloride
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08686150B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-013566ac2b2a45b3b71b057b2fd9f1a5 |
| Source note | uspto-grants-2014_04 |