Hydrochloric Acid → HCID 178434397, compound

HRID 2360690Notes

Reaction equation

HRID 2360690 reaction equation
[CH3:1][C:2]1([NH:8][C:9]([C:11]2[C:12]3[C:26]([CH3:27])=[N:25][N:24](C4CCCCO4)[C:13]=3[N:14]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=3)[CH:16]=2)=[O:10])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl>C1COCC1>[CH3:1][C:2]1([NH:8][C:9]([C:11]2[C:12]3[C:26]([CH3:27])=[N:25][NH:24][C:13]=3[N:14]=[C:15]([C:17]3[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=3)[CH:16]=2)=[O:10])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 1363597726-(4-Hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (4-methyl-piperidin-4-yl)-amide

Product 1

HCID 178434397HCID 178434397, compoundYield 118.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 6-(4-hydroxy-phenyl)-3-methyl-1-(tetrahydro-pyran-2-yl)-1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid (4-methyl-piperidin-4-yl)-amide (75 mg) in THF (1 mL) was added to a stirred solution of HCl (4N in dioxane). The mixture was stirred at r.t. overnight, the precipitate formed was filtered off and washed with ethyl acetate and acetone and dried in air to give 72 mg (99%) of the title compound as hydrochloride

Workup

  1. customthe precipitate formed
  2. filtrationwas filtered off
  3. washwashed with ethyl acetate and acetone
  4. customdried in air

Sources & evidence

ORD record
ord-013566ac2b2a45b3b71b057b2fd9f1a5
Source dataset
uspto-grants-2014_04
Patent number
US08686150B2

Reaction notes

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