反应详情

1.4 g of 6-(4-hydroxy-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid methyl ester were dissolved in 50 mL of a mixture of 2N LiOH and methanol (1:1). After the reaction was complete, methanol was removed in vacuo, water was added and the solution acidified to pH 1 by addition of hydrochloric acid. The resulting precipitate was filtered off to give 1.25 g of the title compound.

1. custommethanol was removed in vacuo, water
2. additionwas added
3. additionthe solution acidified to pH 1 by addition of hydrochloric acid
4. filtrationThe resulting precipitate was filtered off